Comparative study between conventional and 4 mm manual small-incision cataract surgery

Purpose: Comparative study of intraoperative and postoperative complications, visual outcomes, and cost?effectiveness between conventional and 4?mm manual small?incision cataract surgery with MVR blade. Methods: In total, 600 patients having nuclear sclerosis grade I朓V were operated under peribulbar anesthesia and were divided into two groups of 300 each. In group A (300), conventional small?incision cataract surgery was done, whereas in group B (300), 4?mm manual small?incision cataract surgery was performed through a 4?mm sclerocorneal tunnel. A wire vectis was passed through the 4?mm incision below the nucleus to stabilize it, and a 20?G MVR blade was introduced from 11o抍lock limbus and nucleus was bisected into two halves, which were removed through main incision. Cortical wash was given, and foldable IOL was implanted. Intraoperative and postoperative complications between the two groups were compared. Postoperative visual outcome and surgically induced astigmatism between the two groups was studied. Results: The most common intraoperative complication was hyphema (11.33%) and irido?dialysis (8.00%), whereas postoperatively, striate keratopathy (36.33%) and hyphema (19.33%) were common. Short?term complications such as striate keratopathy, hyphema, and irido?dialysis were significantly more in group B, and long?term results in terms of visual outcome and surgically induced astigmatism were significantly less in group B. Conclusion: Although intraoperative and short?term postoperative complications were observed more in 4?mm manual small?incision cataract surgery, it was found to be more effective in terms of surgically induced astigmatism and final visual outcome. In addition, it is cost?effective as compared to phacoemulsification.

Oral care in cancer nursing: Practice and barriers

Background: Oral health awareness and oral care are crucial aspects of oncology nursing practice. However, very few studies concentrate on the oral care of cancer patients undergoing cancer treatment and nursing practice in the Indian subcontinent scenario/situation. Most of the published studies have been conducted in the Western and European countries. Aims: This study aimed to determine the nurses' practice and barriers regarding oral care in cancer patients undergoing chemotherapy and radiation therapy. Materials and Methods: A cross-sectional descriptive survey was conducted among 158 staff nurses working in oncology-related areas from four different hospitals of Dakshina Kannada district and Udupi district of Karnataka state, India. Statistical Analysis: Descriptive and inferential statistics was used by using SPSS 16 version. Results: More than half of respondents [54 (34.2%)] did not perform oral care as a part of routine duties. Maintenance of various records, lack of manpower, and lack of standard operating procedures were major barriers in providing oral care. Documentation audit revealed that nurses recorded oral care in the chart only when order was present in the care sheet, but oral problem assessment was not recorded at all. In all four hospitals surveyed, there was no protocol specifically designed for oral care of cancer patients. Conclusion: Nurses expressed that oral care in cancer patients was one of the most ignored aspect in oncology nursing. Our result highlights the need to develop evidence-based oral care intervention protocol and motivate staff nurses to attend continuing nursing educations regularly to keep themselves abreast of the latest trends in order to render comprehensive care to the patients.

Conformational study of N-methylated alanine peptides and design of Aẞ inhibitor.

N-Methylation increases the proteolytic stability of peptides and leads to improved pharmacological and increased nematicidal property against plant pathogens. In this study, the quantum mechanical and molecular dynamic simulation approaches were used to investigate conformational behavior of peptides containing only N-methylated alanine (NMeAla) residues and N-methylated alanine and alanine residues at alternate positions. The amide bond geometry was found to be trans and the poly NMeAla peptides were shown to populate in the helical structure without hydrogen bond with , values of ~ 0, 90˚ stabilized by carbonyl-carbonyl interactions. Molecular dynamic simulations in water/methanol revealed the formation of β-strand structure, irrespective of the starting geometry due to the interaction of solvent molecules with the carbonyl groups of peptide backbone. Analysis of simulation results as a function of time suggested that the opening of helical structure without hydrogen bond started from C-terminal. Conformational behavior of peptides containing N-MeAla and Ala was used to design Ab peptide inhibitor and the model tetrapeptide Ac-Ala-NMeAla-Ala-NHMe in the β-strand structure was shown to interact with the hydrophobic stretch of Aβ15-42 peptide.

Original research paper an autopsy study of socio-etiological aspects in dowry death cases.

Violence affects lives of millions of woman worldwide, in all societies, one of the most heinous and shocking forms among them is DOWRY DEATH, is one among the various reasons for suicidal (i.e. abetted suicide) and homicidal deaths of women in India, other being marital infidelity, sexual jealousy etc. This study done at Kempegowda Institute of Medical Sciences and Research Hospital, Bangalore South, was conducted during the period July 2006 to January 2008, aims and objectives were to know the magnitude, socio etiologic profile and methods used for committing suicide/homicide, and various other factors affecting the alarming rise in incidence of dowry death and also to lend valuable suggestion to concerned authorities to prevent this heinous social evil of our society. Most of the victims were aged between 18 to 25 years of age, maximum of the victims died within three years of married life, most commonly between 1 to 2 years of married life. Hanging is the most common method used for dowry deaths.

Head injuries in children resulting from the fall of television.

Case records of children admitted with head injury due to TV fall in a pediatric tertiary care hospital in Chennai, during March 2007 – February 2008 were analysed retrospectively. Out of the 11 children admitted 6 (54%) were in 1-2 yr age group. Bleeding from the ear, nose and throat was the commonest, finding followed by a skull fracture, seen on imaging studies. These were observed in 9 (81.81%) and 8(72.8%) children respectively. There was no mortality.